Spyros Papageorgiou’s main scientific interests encompass biological and mechanical aspects of orthodontic treatment, giving emphasis in improving treatment outcome and reducing treatment duration and side-effects. His focus is on evidence-based orthodontics founded on systematic reviews with conventional meta-analysis or network meta-analysis of randomized clinical trials, clinical trials assessing the comparative effectiveness or adverse effects of different orthodontic treatment modalities, factors influencing the length and outcome of orthodontic treatment, sources of bias in clinical research in orthodontics, optimization of treatment mechanics to enhance their efficiency by investigating clinical scenarios with numerical (finite element) simulations, and the effect of health and systematic diseases on the biology of orthodontic tooth movement.
Papageorgiou SN, Zogakis IP, Papadopoulos MA. Failure rates and associated risk factors of orthodontic miniscrew implants: A meta-analysis. Am J Orthod Dentofacial Orthop 2012;11:577-595.e7.
Papageorgiou SN, Xavier GM, Cobourne MT. Basic study design influences treatment effect when undertaking clinical orthodontic investigations. J Clin Epidemiol 2015;68:1512-1522.
Papageorgiou SN, Papageorgiou PN, Deschner J, Götz W. Comparative effectiveness of natural and synthetic bone grafts in oral and maxillofacial surgery prior to insertion of dental implants: Systematic review and network meta-analysis of parallel and cluster randomized controlled trials. J Dent 2016;48:1-8.
DiBiase A, Woodhouse NR, Papageorgiou SN, Slipper C, Grant J, Alsaleh M, Cobourne MT. Effect of supplemental vibrational force on orthodontically-induced inflammatory root resorption - a multicenter randomized clinical trial. Am J Orthod Dentofac Orthop 2016;150:918-927.
Papageorgiou SN, Sifakakis I, Keilig L, Affolter S, Patcas R, Eliades T, Bourauel C. Torque differences according to tooth morphology and bracket placement: a finite element study. Eur J Orthod 2016 [Epub ahead of print].
Saloom HF, Papageorgiou SN, Carpenter GH, Cobourne MT. Impact of obesity on orthodontic tooth movement: a prospective cohort study. J Dent Res J Dent Res 2017;96:547-554.