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Institut für Parasitologie

Publications

Girard, A. et al. (2021) Raman spectroscopic analysis of skin as a diagnostic tool for Human African Trypanosomiasis. PLoS Pathogens, 17(11), e1010060. (doi: 10.1371/journal.ppat.1010060) (PMID:34780575) (PMCID:PMC8629383)

Wickenhagen, A. et al. (2021) A prenylated dsRNA sensor protects against severe COVID-19. Science, 374(6567), eabj3624. (doi: 10.1126/science.abj3624) (PMID:34581622)

Silva-Filho, J. L. et al. (2021) Total parasite biomass but not peripheral parasitaemia is associated with endothelial and haematological perturbations in Plasmodium vivax patients. eLife, 10, e71351. (doi: 10.7554/eLife.71351) (PMID:34585667) (PMCID:PMC8536259)

Meibalan, E. et al. (2021) Plasmodium falciparum gametocyte density and infectivity in peripheral blood and skin tissue of naturally infected parasite carriers in Burkina Faso. Journal of Infectious Diseases, 223(10), pp. 1822-1830. (doi: 10.1093/infdis/jiz680) (PMID:31875909) (PMCID:PMC8161640)

Kho, S. et al. (2021) Evaluation of splenic accumulation and colocalization of immature reticulocytes and Plasmodium vivax in asymptomatic malaria: a prospective human splenectomy study. PLoS Medicine, 18(5), e1003632. (doi: 10.1371/journal.pmed.1003632) (PMID:34038413) (PMCID:PMC8154101)

Barry, A. et al. (2021) Higher gametocyte production and mosquito infectivity in chronic compared to incident Plasmodium falciparum infections. Nature Communications, 12, 2443. (doi: 10.1038/s41467-021-22573-7) (PMID:33903595) (PMCID:PMC8076179)

Mejia, P. et al. (2021) Adipose tissue parasite sequestration drives leptin production in mice and correlates with human cerebral malaria. Science Advances, 7(13), eabe2484. (doi: 10.1126/sciadv.abe2484) (PMID:33762334) (PMCID:PMC7990332)

Buyon, L. E. et al. (2020) Population genomics of Plasmodium vivax in Panama to assess the risk of case importation on malaria elimination. PLoS Neglected Tropical Diseases, 14(12), e0008962. (doi: 10.1371/journal.pntd.0008962) (PMID:33315861) (PMCID:PMC7769613)

Hentzschel, F., Obrova, K. and Marti, M. (2020) No evidence for Ago2 translocation from the host erythrocyte into the Plasmodium parasite. Wellcome Open Research, 5, 92. (doi: 10.12688/wellcomeopenres.15852.2) (PMID:33501380) (PMCID:PMC7808052)

Hung, J. et al. (2020) Keras R-CNN: library for cell detection in biological images using deep neural networks. BMC Bioinformatics, 21, 300. (doi: 10.1186/s12859-020-03635-x) (PMID:32652926) (PMCID:PMC7353739)

Silva-Filho, J. L. , Lacerda, M. V.G., Recker, M., Wassmer, S. C., Marti, M. and Costa, F. T.M. (2020) Plasmodium vivax in hematopoietic niches: hidden and dangerous. Trends in Parasitology, 36(5), pp. 447-458. (doi: 10.1016/j.pt.2020.03.002) (PMID:32298632)

Venugopal, K. , Hentzschel, F., Valkiūnas, G. and Marti, M. (2020) Plasmodium asexual growth and sexual development in the haematopoietic niche of the host. Nature Reviews Microbiology, 18(3), pp. 177-189. (doi: 10.1038/s41579-019-0306-2) (PMID:31919479)

Meehan, G. R. , Scales, H. E. , Osii, R., De Niz, M., Lawton, J. C., Marti, M. , Garside, P. , Craig, A. and Brewer, J. M. (2020) Developing a xenograft model of human vasculature in the mouse ear pinna. Scientific Reports, 10, 2058. (doi: 10.1038/s41598-020-58650-y) (PMID:32029768) (PMCID:PMC7004987)

Moxon, C. A. , Gibbins, M. P. , McGuinness, D., Milner, D. A. and Marti, M. (2020) New insights into malaria pathogenesis. Annual Review of Pathology: Mechanisms of Disease, 15(1), pp. 315-343. (doi: 10.1146/annurev-pathmechdis-012419-032640) (PMID:31648610)

Alam, M. M. et al. (2019) Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target. Science, 365(6456), eaau1682. (doi: 10.1126/science.aau1682) (PMID:31467193)

Ngotho, P., Blancke Soares, A., Hentzschel, F., Achcar, F. , Bertuccini, L. and Marti, M. (2019) Revisiting gametocyte biology in malaria parasites. FEMS Microbiology Reviews, 43(4), pp. 401-414. (doi: 10.1093/femsre/fuz010) (PMID:31220244) (PMCID:PMC6606849)

Dantzler, K. W. et al. (2019) Naturally acquired immunity against immature Plasmodium falciparum gametocytes. Science Translational Medicine, 11(495), eaav3963. (doi: 10.1126/scitranslmed.aav3963) (PMID:31167926) (PMCID:PMC6653583)

De Niz, M., Meehan, G. R. , Brancucci, N. M.B. , Marti, M. , Rotureau, B., Figueiredo, L. M. and Frischknecht, F. (2019) Intravital imaging of host-parasite interactions in skin and adipose tissues. Cellular Microbiology, 21(5), e13023. (doi: 10.1111/cmi.13023) (PMID:30825872)

De Niz, M., Spadin, F., Marti, M. , Stein, J. V., Frenz, M. and Frischknecht, F. (2019) Toolbox for in vivo imaging of host-parasite interactions at multiple scales. Trends in Parasitology, 35(3), pp. 193-212. (doi: 10.1016/j.pt.2019.01.002) (PMID:30745251)

Sollelis, L. and Marti, M. (2018) A major step towards defining the elusive stumpy inducing factor in Trypanosoma brucei. Trends in Parasitology, 35(1), pp. 6-8. (doi: 10.1016/j.pt.2018.11.009) (PMID:30554967)

Brancucci, N. M.B. , De Niz, M., Straub, T. J., Ravel, D., Sollelis, L., Birren, B. W., Voss, T. S., Neafsey, D. E. and Marti, M. (2018) Probing Plasmodium falciparum sexual commitment at the single-cell level. Wellcome Open Research, 3, 70. (doi: 10.12688/wellcomeopenres.14645.4) (PMID:30320226) (PMCID:PMC6143928)

De Niz, M. et al. (2018) Plasmodium gametocytes display homing and vascular transmigration in the host bone marrow. Science Advances, 4(5), eaat3775. (doi: 10.1126/sciadv.aat3775) (PMID:29806032) (PMCID:PMC5966192)

Obaldia III, N. et al. (2018) Bone marrow is a major parasite reservoir in Plasmodium vivax infection. mBio, 9(3), e00625-18. (doi: 10.1128/mBio.00625-18) (PMID:29739900)

Fraschka, S. A. et al. (2018) Comparative heterochromatin profiling reveals conserved and unique epigenome signatures linked to adaptation and development of malaria parasites. Cell Host and Microbe, 23(3), 407-420.e8. (doi: 10.1016/j.chom.2018.01.008) (PMID:29503181)

Stone, W. J.R. et al. (2018) Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity. Nature Communications, 9, 558. (doi: 10.1038/s41467-017-02646-2) (PMID:29422648) (PMCID:PMC5805765)

Meerstein-Kessel, L. et al. (2018) Probabilistic data integration identifies reliable gametocyte-specific proteins and transcripts in malaria parasites. Scientific Reports, 8, 410. (doi: 10.1038/s41598-017-18840-7) (PMID:29323249) (PMCID:PMC5765010)

Nilsson Bark, S. K. et al. (2018) Quantitative proteomic profiling reveals novel Plasmodium falciparum surface antigens and possible vaccine candidates. Molecular and Cellular Proteomics, 17(1), pp. 43-60. (doi: 10.1074/mcp.RA117.000076) (PMID:29162636)

Brancucci, N. M.B. et al. (2017) Lysophosphatidylcholine regulates sexual Stage differentiation in the human malaria parasite Plasmodium falciparum. Cell, 171(7), 1532-1544.e15. (doi: 10.1016/j.cell.2017.10.020) (PMID:29129376) (PMCID:PMC5733390)

Mejia, P., Treviño-Villarreal, J. H., Reynolds, J. S., De Niz, M., Thompson, A., Marti, M. and Mitchell, J. R. (2017) A single rapamycin dose protects against late-stage experimental cerebral malaria via modulation of host immunity, endothelial activation and parasite sequestration. Malaria Journal, 16, 455. (doi: 10.1186/s12936-017-2092-5) (PMID:29121917) (PMCID:PMC5679345)

Meibalan, E. and Marti, M. (2017) Biology of malaria transmission. Cold Spring Harbor Perspectives in Medicine, 7(3), a025452. (doi: 10.1101/cshperspect.a025452) (PMID:27836912)

Coalson, J. E. et al. (2016) High prevalence of Plasmodium falciparum gametocyte infections in school-age children using molecular detection: patterns and predictors of risk from a cross-sectional study in southern Malawi. Malaria Journal, 15(1), 527. (doi: 10.1186/s12936-016-1587-9) (PMID:27809907) (PMCID:PMC5096312)

Kato, N. et al. (2016) Diversity-oriented synthesis yields novel multistage antimalarial inhibitors. Nature, 538(7625), pp. 344-349. (doi: 10.1038/nature19804) (PMID:27602946) (PMCID:PMC5515376)

Mantel, P.-Y. et al. (2016) Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria. Nature Communications, 7, 12727. (doi: 10.1038/ncomms12727) (PMID:27721445) (PMCID:PMC5062468)

Marti, M. and Johnson, P. J. (2016) Emerging roles for extracellular vesicles in parasitic infections. Current Opinion in Microbiology, 32, pp. 66-70. (doi: 10.1016/j.mib.2016.04.008) (PMID:27208506)

Marti, M. and Hill, K. L. (2016) Sensing and signaling in parasitism. Molecular and Biochemical Parasitology, 208(1), p. 1. (doi: 10.1016/j.molbiopara.2016.07.010) (PMID:27546054) (PMCID:PMC5208041)

Joice, R. et al. (2016) Evidence for spleen dysfunction in malaria-HIV co-infection in a subset of pediatric patients. Modern Pathology, 29(4), pp. 381-390. (doi: 10.1038/modpathol.2016.27) (PMID:26916076) (PMCID:PMC4811692)

STONE, W. J. R., DANTZLER, K. W., NILSSON, S. K., DRAKELEY, C. J., MARTI, M. , BOUSEMA, T. and RIJPMA, S. R. (2016) Naturally acquired immunity to sexual stage P. falciparum parasites. Parasitology, 143(02), pp. 187-198. (doi: 10.1017/S0031182015001341) (PMID:26743529)

Chang, H.-H. et al. (2016) Persistence of Plasmodium falciparum parasitemia after artemisinin combination therapy: evidence from a randomized trial in Uganda. Scientific Reports, 6, p. 26330. (doi: 10.1038/srep26330) (PMID:27197604) (PMCID:PMC4873826)

Obaldía III, N. et al. (2016) Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model. Scientific Reports, 6, 21216. (doi: 10.1038/srep21216) (PMID:26880111) (PMCID:PMC4754742)

Pellé, K. G., Jiang, R. H. Y., Mantel, P.-Y., Xiao, Y.-P., Hjelmqvist, D., Gallego-Lopez, G. M., O.T. Lau, A., Kang, B.-H., Allred, D. R. and Marti, M. (2015) Shared elements of host-targeting pathways among apicomplexan parasites of differing lifestyles. Cellular Microbiology, 17(11), pp. 1618-1639. (doi: 10.1111/cmi.12460) (PMID:25996544)

Gulati, S. et al. (2015) Profiling the essential nature of lipid metabolism in asexual blood and gametocyte stages of Plasmodium falciparum. Cell Host and Microbe, 18(3), pp. 371-381. (doi: 10.1016/j.chom.2015.08.003) (PMID:26355219) (PMCID:PMC4567697)

Brancucci, N. M. B., Goldowitz, I., Buchholz, K., Werling, K. and Marti, M. (2015) An assay to probe Plasmodium falciparum growth, transmission stage formation and early gametocyte development. Nature Protocols, 10(8), pp. 1131-1142. (doi: 10.1038/nprot.2015.072) (PMID:26134953) (PMCID:PMC4581880)

Dantzler, K. W., Ravel, D. B., Brancucci, N. M. and Marti, M. (2015) Ensuring transmission through dynamic host environments: host–pathogen interactions in Plasmodium sexual development. Current Opinion in Microbiology, 26, pp. 17-23. (doi: 10.1016/j.mib.2015.03.005) (PMID:25867628) (PMCID:PMC4577303)

Nilsson, S. K., Childs, L. M., Buckee, C. and Marti, M. (2015) Targeting human transmission biology for malaria elimination. PLoS Pathogens, 11(6), e1004871. (doi: 10.1371/journal.ppat.1004871) (PMID:26086192) (PMCID:PMC4472755)

Choi, J.-Y., Duraisingh, M. T., Marti, M. , Ben Mamoun, C. and Voelker, D. R. (2015) From protease to decarboxylase: the molecular metamorphosis of phosphatidylserine decarboxylase. Journal of Biological Chemistry, 290(17), pp. 10972-10980. (doi: 10.1074/jbc.M115.642413) (PMID:25724650) (PMCID:PMC4409258)

Obaldia, N. et al. (2015) Clonal outbreak of Plasmodium falciparum infection in Eastern Panama. Journal of Infectious Diseases, 211(7), pp. 1087-1096. (doi: 10.1093/infdis/jiu575) (PMID:25336725) (PMCID:PMC4366603)

Pelle, K. G. et al. (2015) Transcriptional profiling defines dynamics of parasite tissue sequestration during malaria infection. Genome Medicine, 7(1), 19. (doi: 10.1186/s13073-015-0133-7) (PMID:25722744) (PMCID:PMC4342211)

Tao, D. et al. (2014) Sex-partitioning of the Plasmodium falciparum stage V gametocyte proteome provides insight into falciparum-specific cell biology. Molecular and Cellular Proteomics, 13(10), pp. 2705-2724. (doi: 10.1074/mcp.M114.040956) (PMID:25056935) (PMCID:PMC4188997)

Coleman, B. I. et al. (2014) A Plasmodium falciparum histone deacetylase regulates antigenic variation and gametocyte conversion. Cell Host and Microbe, 16(2), pp. 177-186. (doi: 10.1016/j.chom.2014.06.014) (PMID:25121747) (PMCID:PMC4188636)

Joice, R. et al. (2014) Plasmodium falciparum transmission stages accumulate in the human bone marrow. Science Translational Medicine, 6(244), 244re5. (doi: 10.1126/scitranslmed.3008882) (PMID:25009232) (PMCID:PMC4175394)

Ankarklev, J., Brancucci, N. M.B., Goldowitz, I., Mantel, P.-Y. and Marti, M. (2014) Sex: how malaria parasites get turned on. Current Biology, 24(9), R368-R370. (doi: 10.1016/j.cub.2014.03.046) (PMID:24801188)

Mantel, P.-Y. and Marti, M. (2014) The role of extracellular vesicles in Plasmodium and other protozoan parasites. Cellular Microbiology, 16(3), pp. 344-354. (doi: 10.1111/cmi.12259) (PMID:24406102) (PMCID:PMC3965572)

Aguilar, R. et al. (2014) Molecular evidence for the localization of Plasmodium falciparum immature gametocytes in bone marrow. Blood, 123(7), pp. 959-966. (doi: 10.1182/blood-2013-08-520767) (PMID:24335496) (PMCID:PMC4067503)

Przytycka, T. M. et al. (2013) Inferring developmental stage composition from gene expression in human malaria. PLoS Computational Biology, 9(12), e1003392. (doi: 10.1371/journal.pcbi.1003392) (PMID:24348235) (PMCID:PMC3861035)

Mantel, P.-Y. et al. (2013) Malaria-infected erythrocyte-derived microvesicles mediate cellular communication within the parasite population and with the host immune system. Cell Host and Microbe, 13(5), pp. 521-534. (doi: 10.1016/j.chom.2013.04.009) (PMID:23684304) (PMCID:PMC3687518)

Hanson, K.K. et al. (2013) Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins. Proceedings of the National Academy of Sciences of the United States of America, 110(30), E2838-E2847. (doi: 10.1073/pnas.1306097110) (PMID:23836641) (PMCID:PMC3725106)

Marti, M. and Spielmann, T. (2013) Protein export in malaria parasites: many membranes to cross. Current Opinion in Microbiology, 16(4), pp. 445-451. (doi: 10.1016/j.mib.2013.04.010) (PMID:23725671) (PMCID:PMC3755040)

Vorobjev, I. A., Buchholz, K., Prabhat, P., Ketman, K., Egan, E. S., Marti, M. , Duraisingh, M. T. and Barteneva, N. S. (2012) Optimization of flow cytometric detection and cell sorting of transgenic Plasmodium parasites using interchangeable optical filters. Malaria Journal, 11(1), p. 312. (doi: 10.1186/1475-2875-11-312) (PMID:22950515) (PMCID:PMC3544587)

Aingaran, M. et al. (2012) Host cell deformability is linked to transmission in the human malaria parasite Plasmodium falciparum. Cellular Microbiology, 14(7), pp. 983-993. (doi: 10.1111/j.1462-5822.2012.01786.x) (PMID:22417683) (PMCID:PMC3376226)

da Cruz, F. P. et al. (2012) Drug screen targeted at plasmodium liver stages identifies a potent multistage antimalarial drug. Journal of Infectious Diseases, 205(8), pp. 1278-1286. (doi: 10.1093/infdis/jis184) (PMID:22396598) (PMCID:PMC3308910)

Jiang, R. H.Y. and Marti, M. (2012) A PIP gets the Plasmodium protein export pathway going. Cell Host and Microbe, 11(2), pp. 99-100. (doi: 10.1016/j.chom.2012.01.011) (PMID:22341457)

Morahan, B. J., Strobel, C., Hasan, U., Czesny, B., Mantel, P.-Y., Marti, M. , Eksi, S. and Williamson, K. C. (2011) Functional analysis of the exported type IV HSP40 Protein PfGECO in Plasmodium falciparum gametocytes. Eukaryotic Cell, 10(11), pp. 1492-1503. (doi: 10.1128/EC.05155-11) (PMID:21965515) (PMCID:PMC3209067)

Buchholz, K., Burke, T. A., Williamson, K. C., Wiegand, R. C., Wirth, D. F. and Marti, M. (2011) A high-throughput screen targeting malaria transmission stages opens new avenues for drug development. Journal of Infectious Diseases, 203(10), pp. 1445-1453. (doi: 10.1093/infdis/jir037) (PMID:21502082) (PMCID:PMC3080890)

Struck, N. S. et al. (2008) Spatial dissection of the cis- and trans-Golgi compartments in the malaria parasite Plasmodium falciparum. Molecular Microbiology, 67(6), pp. 1320-1330. (doi: 10.1111/j.1365-2958.2008.06125.x) (PMID:18284574)

Struck, N. S. et al. (2008) Plasmodium falciparum possesses two GRASP proteins that are differentially targeted to the Golgi complex via a higher- and lower-eukaryote-like mechanism. Journal of Cell Science, 121(13), pp. 2123-2129. (doi: 10.1242/jcs.021154) (PMID:18522993)

Maier, A. G., Rug, M., O'Neill, M. T., Beeson, J. G., Marti, M. , Reeder, J. and Cowman, A. F. (2007) Skeleton-binding protein 1 functions at the parasitophorous vacuole membrane to traffic PfEMP1 to the Plasmodium falciparum-infected erythrocyte surface. Blood, 109(3), pp. 1289-1297. (doi: 10.1182/blood-2006-08-043364) (PMID:17023587) (PMCID:PMC1785152)

Cooke, B. M., Buckingham, D. W., Glenister, F. K., Fernandez, K. M., Bannister, L. H., Marti, M. , Mohandas, N. and Coppel, R. L. (2006) A Maurer's cleft–associated protein is essential for expression of the major malaria virulence antigen on the surface of infected red blood cells. Journal of Cell Biology, 172(6), pp. 899-908. (doi: 10.1083/jcb.200509122) (PMID:16520384) (PMCID:PMC2063733)

Sargeant, T. J., Marti, M. , Caler, E., Carlton, J. M., Simpson, K., Speed, T. P. and Cowman, A. F. (2006) Lineage-specific expansion of proteins exported to erythrocytes in malaria parasites. Genome Biology, 7(2), R12. (doi: 10.1186/gb-2006-7-2-r12) (PMID:16507167) (PMCID:PMC1431722)

Struck, N. S., de Souza Dias, S., Langer, C., Marti, M. , Pearce, J. A., Cowman, A. F. and Gilberger, T. W. (2005) Re-defining the Golgi complex in Plasmodium falciparum using the novel Golgi marker PfGRASP. Journal of Cell Science, 118(23), pp. 5603-5613. (doi: 10.1242/jcs.02673) (PMCID:16306223)

Marti, M. , Baum, J., Rug, M., Tilley, L. and Cowman, A. F. (2005) Signal-mediated export of proteins from the malaria parasite to the host erythrocyte. Journal of Cell Biology, 171(4), pp. 587-592. (doi: 10.1083/jcb.200508051) (PMID:16301328) (PMCID:PMC2171567)

van Dooren, G. G., Marti, M. , Tonkin, C. J., Stimmler, L. M., Cowman, A. F. and McFadden, G. I. (2005) Development of the endoplasmic reticulum, mitochondrion and apicoplast during the asexual life cycle of Plasmodium falciparum. Molecular Microbiology, 57(2), pp. 405-419. (doi: 10.1111/j.1365-2958.2005.04699.x) (PMID:15978074)

Marti, M. , Good, R. T., Rug, M., Knueppfer, E. and Cowman, A. F. (2004) Targeting malaria virulence and remodeling proteins to the host erythrocyte. Science, 306(5703), pp. 1930-1933. (doi: 10.1126/science.1102452) (PMID:15591202)

Hehl, A. B. and Marti, M. (2004) Secretory protein trafficking in Giardia intestinalis. Molecular Microbiology, 53(1), pp. 19-28. (doi: 10.1111/j.1365-2958.2004.04115.x) (PMID:15225300)

Marti, M. and Hehl, A. B. (2003) Encystation-specific vesicles in Giardia: a primordial Golgi or just another secretory compartment? Trends in Parasitology, 19(10), pp. 440-446. (doi: 10.1016/S1471-4922(03)00201-0) (PMID:14519581)

Marti, M. , Regös, A., Li, Y., Schraner, E. M., Wild, P., Müller, N., Knopf, L. G. and Hehl, A. B. (2003) An ancestral secretory apparatus in the protozoan parasite Giardia intestinalis. Journal of Biological Chemistry, 278(27), pp. 24837-24848. (doi: 10.1074/jbc.M302082200) (PMID:12711599)

Marti, M. , Li, Y., Schraner, E. M., Wild, P., Köhler, P. and Hehl, A. B. (2003) The secretory apparatus of an ancient eukaryote: protein sorting to separate export pathways occurs before formation of transient Golgi-like compartments. Molecular Biology of the Cell, 14(4), pp. 1433-1447. (doi: 10.1091/mbc.E02-08-0467) (PMID:12686599) (PMCID:PMC153112)

Marti, M. , Li, Y., Köhler, P. and Hehl, A. B. (2002) Conformationally correct expression of membrane-anchored Toxoplasma gondii SAG1 in the primitive protozoan Giardia duodenalis. Infection and Immunity, 70(2), pp. 1014-1016. (doi: 10.1128/IAI.70.2.1014-1016.2002) (PMID:11796643) (PMCID:PMC127713)

Hehl, A. B., Marti, M. and Köhler, P. (2000) Stage-specific expression and targeting of cyst wall protein-green fluorescent protein chimeras in Giardia. Molecular Biology of the Cell, 11(5), pp. 1789-1800. (doi: 10.1091/mbc.11.5.1789) (PMID:10793152) (PMCID:PMC14884)

Subramanian, A. B., Navarro, S., Carrasco, R. A., Marti, M. and Das, S. (2000) Role of exogenous inositol and phosphatidylinositol in glycosylphosphatidylinositol anchor synthesis of GP49 by Giardia lamblia. Biochimica et Biophysica Acta: Molecular and Cell Biology of Lipids, 1483(1), pp. 69-80. (doi: 10.1016/S1388-1981(99)00171-7) (PMID:10601696)