Head and neck cancer defines a group of solid tumors originating from the epithelium of the upper aerodigestive tract, pharynx, larynx, mouth, salivary glands and nasal cavity. The most common subtype, the squamous cell carcinoma (HNSCC), affects mostly structures in the oral cavity and particularly the tongue. It is the sixth most common cancer in the world, has metastatic evolution and poor prognosis. HNSCC heterogeneity and complexity reflects in a multistep progression, involving crosstalk between several molecular pathways. Squamous epithelium remain undifferentiated, recapitulating molecular and cellular events typical of the embryonic developmental period. Importantly, the Notch pathway, pivotal during embryonic life, is associated with major events supporting cancerogenic evolution: cell proliferation, self-renewal, angiogenesis, and preservation of a pro-oncogenic microenvironment. Using cutting-edge technologies (advanced imaging, transgenesis and NGS), we study the parallelisms between embryonic development and tumorigenesis, with particular focus on the role of the Notch pathway in epithelium. Our studies aim to identify the major molecular players that sustain cancer, with the ultimate goal to identify druggable targets and develop more effective treatments.
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Adv Exp Med Biol. 2021;1287:81-103. doi: 10.1007/978-3-030-55031-8_7. PMID: 33034028
Porcheri C, Golan O, Calero-Nieto FJ, Thambyrajah R, Ruiz-Herguido C, Wang X, Catto F, Guillén Y, Sinha R, González J, Kinston SJ, Mariani SA, Maglitto A, Vink CS, Dzierzak E, Charbord P, Göttgens B, Espinosa L, Sprinzak D, Bigas A (2020) Notch ligand Dll4 impairs cell recruitment to aortic clusters and limits blood stem cell generation.
EMBO J. 2020 Apr 15;39(8):e104270. doi: 10.15252/embj.2019104270. Epub 2020 Mar 9. PMID: 32149421
Meisel CT, Pagella P, Porcheri C, Mitsiadis TA (2020) Three-Dimensional Imaging and Gene Expression Analysis Upon Enzymatic Isolation of the Tongue Epithelium.
Front Physiol. 2020 Jul 21;11:825. doi: 10.3389/fphys.2020.00825. eCollection 2020. PMID: 32848819
Meisel CT, Porcheri C, Mitsiadis TA (2020) Cancer Stem Cells, Quo Vadis? The Notch Signaling Pathway in Tumor Initiation and Progression.
Cells. 2020 Aug 11;9(8):1879. doi: 10.3390/cells9081879. PMID: 32796631
Porcheri C, Meisel CT, Mitsiadis TA (2020) Molecular and Cellular Modelling of Salivary Gland Tumors Open New Landscapes in Diagnosis and Treatment.
Cancers (Basel). 2020 Oct 24;12(11):3107. doi: 10.3390/cancers12113107. PMID: 33114321
Porcheri C, Meisel CT, Mitsiadis T (2019) Multifactorial Contribution of Notch Signaling in Head and Neck Squamous Cell Carcinoma.
Int J Mol Sci. 2019 Mar 26;20(6):1520. doi: 10.3390/ijms20061520. PMID: 30917608