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Center for Dental Medicine

Sybille Schwendener, PhD

Wissenschaftliche Mitarbeiterin at the Clinic of Conservative and Preventive Dentistry

Sybille Schwendener, PhD
Contact: E-Mail: sybille.schwendener@zzm.uzh.ch
Qualifications: PhD, MSc (Diploma) ETHZ
Affiliation:

Division of Clinical Oral Microbiology and Immunology, Clinic of Conservative and Preventive Dentistry

Research Interests

  • Multispecies oral biofilm models (physiology and 3D structure of biofilms under changing conditions)
  • Composition and characteristics of the extracellular matrix in oral biofilms
  • Inter- and intra-species interaction within oral biofilms in health and disease
  • Interaction between oral biofilm and host cells
  • Antimicrobial resistance of planktonic and adherent oral microorganisms
  • Mobile genetic elements and horizontal gene transfer in Streptococcus spp.
  • Identification of oral bacteria using modern techniques (e.g., fluorescent in situ hybridization (FISH), next-generation sequencing, MALDI-TOF MS, confocal laser scanning microscopy (CLSM), real-time PCR, etc.)

Selected publications

Schwendener S, Perreten V. The bla and mec families of β-lactam resistance genes in the genera Macrococcus, Mammaliicoccus and Staphylococcus: an in-depth analysis with emphasis on Macrococcus. J Antimicrob Chemother. 2022 Jun 29;77(7):1796-1827.

Schwendener S, Donà V, Perreten V. The novel macrolide resistance genes mef(D), msr(F), and msr(H) are present on resistance islands in Macrococcus canis, Macrococcus caseolyticus, and Staphylococcus aureus. Antimicrob Agents Chemother. 2020 Apr 21;64(5):e00160-20.

Schwendener S, Perreten V. The integrase of the Macrococcus caseolyticus resistance island mecD (McRImecD) inserts DNA site-specifically into Staphylococcus and Bacillus chromosomes. Mol Microbiol. 2018 Nov;110(3):455-468.

Schwendener S, Cotting K, Perreten V. Novel methicillin resistance gene mecD in clinical Macrococcus caseolyticus strains from bovine and canine sources. Sci Rep. 2017 Mar 8;7:43797.

Schwendener S, Perreten V. New shuttle vector-based expression system to generate polyhistidine-tagged fusion proteins in Staphylococcus aureus and Escherichia coli. Appl Environ Microbiol. 2015 May1;81(9):3243-54.

Schwendener S, Perreten V. New transposon Tn6133 in methicillin-resistant Staphylococcus aureus ST398 contains vga(E), a novel streptogramin A, pleuromutilin, and lincosamide resistance gene. Antimicrob Agents Chemother. 2011 Oct;55(10):4900-4.

Schwendener S, Raynard S, Paliwal S, Cheng A, Kanagaraj R, Shevelev I, Stark JM, Sung P, Janscak P. Physical interaction of RECQ5 helicase with RAD51 facilitates its anti-recombinase activity. J Biol Chem. 2010 May 21;285(21):15739-45.

Links

PubMed

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